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KMID : 1144020220180010011
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Journal of Korean Association for Disability and Oral Health
2022 Volume.18 No. 1 p.11 ~ p.17
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Oral Manifestations of a Pediatric Patient with Primary Hyperoxaluria Type 1: A Case Report
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Oh Seung-Hyun
Kim Hyun-Tae
Shin Teo-Jeon
Hyun Hong-Keun
Kim Young-Jae
Kim Jung-Wook
Jang Ki-Taeg
Song Ji-Soo
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Abstract
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Primary hyperoxaluria is a rare, genetic metabolic disorder caused by deficiency of alanine-glyoxylate aminotransferase, which results in recurrent kidney stones, parenchymal renal damage, and end-stage renal disease. Patients with primary hyperoxaluria have accumulation of calcium oxalate crystal in most part of the oral cavity, such as bone, periodontal tissues, dentin, cementum, and dental pulp. This report describes a case of 6-year-old boy who was diagnosed with primary hyperoxaluria. For treatment of primary hyperoxaluria, he underwent pre-emptive liver transplant and was on continuous hemodialysis. He has been taking multiple medications, including aspirin. In oral and radiographic examination, generalized root resorption, multiple radiolucent lesions and severe periodontitis were observed. These conditions caused dental pain, worsened tooth mobility, progressive tooth loss and mesial titling of permanent molars. Periodontal treatments including dental scaling were performed under tapered administration of aspirin and prescription of prophylactic antibiotics. Early diagnosis and careful management of the oral conditions would be necessary with the goal of minimizing progression of periodontitis and alveolar bone resorption.
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KEYWORD
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Primary hyperoxaluria, Oral manifestation, Periodontitis, Root resorption, Tooth loss
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